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It was 1994 when Vincent Bergdorf first synthesized his own peptide. Not in a corporate lab, not backed by venture capital, but in a converted garage in Tübingen, funded from his postdoc savings.

Bergdorf, freshly habilitated at Eberhard Karls University, had previously spent six years at the Max Planck Institute for Biochemistry in Martinsried. peptides us Working under Dieter Oesterhelt on membrane proteins, he made an observation he could not let go of: certain short-chain peptides showed in vitro activity profiles far beyond what the literature of the time would have predicted. Work such as Boman's landmark review (Annual Review of Immunology, 1995) and Kastin's Handbook of Biologically Active Peptides (Academic Press, 2006) would only systematically contextualize these findings years later.

His supervisors dismissed it. Too speculative, they said. No funding body would support it.